Hong Kong Dermatology & Venereology Bulletin

Volume 12 Number 2, Summer 2004
Abstract

The effect of chronic cigarette smoking on the response of anogenital wart in male Chinese patients to topical 25% podophyllin therapy
長期吸煙對男性肛門生殖器疣患者接受 25% 鬼臼樹脂治療的影響

MKT Chan 陳錦添, CY Leung 梁志仁, WYM Tang 鄧旭明

A prospective study was carried out from December 1998 to May 1999 in two social hygiene clinics in Hong Kong to evaluate the effect of chronic smoking on clinical response of anogenital wart (AGW) to topical 25% podophyllin therapy. Male smokers and non-smokers with newly diagnosed AGW were recruited for the study. Each patient was treated once every five days consecutively for a maximum of five months and assessed monthly for disappearance of AGW. A total of 178 patients were recruited and 155 patients completed the study. Among these 155 patients, 83 (53.6%) were smokers while 72 (46.4%) were non-smokers. At the end of the first two months, 57 non-smokers but only 30 smokers had their lesions cleared. The difference between the smokers and non-smokers in responding to topical 25% podophyllin therapy at two months interval was statistically significant (c2=29.0, p<0.01). In addition, the association between smoking and susceptibility to AGW was also evaluated. One hundred and ten healthy patients without AGW were served as a control group. A significant association of AGW with chronic cigarette smoking was noted (odds ratio=1.7, confidence intervals=1.05-2.92, p<0.02). We conclude that smokers gave a less favourable response to topical podophyllin treatment compared to the non-smoker counterparts. Further, chronic smokers were more susceptible than non-smokers to development of AGW. (H.K. Dermatol. Venereol. Bull. (2004) 12, 65-70)

筆者於199812月至19995月期間於香港兩間社會衛生科診所進行一項前瞻性研究,評估長期吸煙對以25%鬼臼樹脂治療肛門生殖器疣的影響,募集長期吸煙與非吸煙患者進行研究。患者連續每五天接受治療一次,以五個月為限。每月一次評估疣的消退情況。共募集178人,155人完成研究,其中83人(53.6%)為吸煙者,72(46.4%)為非吸煙者。於首兩個月末,非吸煙治癒者有57人,而吸煙治癒者則僅有30人。此外,對吸煙與罹患肛門生殖器疣的相關性也作了研究。以110位非肛門生殖器疣患者作對照,經排除混淆性因素後,發現肛門生殖器疣與長期吸煙有相關性,其機率比(OR)1.7,置信區間(CI)1.05-2.92,P值<0.02。我們發現吸煙人仕對局部鬼臼樹脂治療的療效較非吸煙者差,而且也更易罹患肛門生殖器疣。

Keywords : Anogenital wart, chronic cigarette smoking, podophyllin

關鍵詞:肛門生殖器疣、長期吸煙、鬼臼樹脂



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