Hong Kong Dermatology & Venereology Bulletin

Volume 11 Number 1, Spring 2003
Abstract

Human Papillomavirus Infections
人類乳頭瘤病毒感染

JYC Lo 羅懿之

Human papillomavirus (HPV) infections are associated with a variety of benign and malignant conditions of the skin and mucous membranes. Of major clinical and public health significance is its relationship with cervical carcinoma. The pathogenetic mechanisms for HPV infection have gradually been elucidated, and the sequence of events in the initiation of carcinogenesis has been established. Laboratory diagnosis of HPV is mainly focused on the use of molecular techniques in cervical specimens for detection of HPV genotypes strongly associated with cervical carcinoma. Various treatment modalities for HPV infections are available, although none is distinctly superior. Prevention strategies are traditionally targeted on avoidance of infection via contact. Recent advances in vaccine development are promising in the prospect of eventual reduction of the disease burden of HPV infection. (H.K. Dermatol. Venereol. Bull. (2003) 11, 9-14)

人類乳頭瘤病毒(HPV)感染與多種皮膚及粘膜的良性及惡性疾病有關。其中極具臨床及公眾健康重要性的是此病毒與子宮頸癌的關係。HPV感染的發病原理正逐步受到遼解,病毒致癌的各階段亦均相繼被確立。HPV的實驗室診斷主要是利用分子生物技術於子宮頸細胞樣本,以檢測與子宮頸癌有尤其密切關係的HPV基因型。治療HPV感染的方法有多種,但沒有一種特別有效。傳統的預防方法是避免從接觸受到感染。新近研制的疫苗將可能有效地控制HPV感染引致的疾病。

Keywords : Hong Kong, human papillomavirus infection, review

關鍵詞:香港,人類乳頭瘤病毒感染,綜述



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