Hong Kong Dermatology & Venereology Bulletin

Volume 10 Number 1, March 2002

Review on Serologic Diagnosis of Syphilis

Dr. K. K. Ho
Social Hygiene Service (Venereology), Department of Health, Hong Kong

In the era of HIV infection, there is a resurgence of syphilis. Despite the advancement of molecular technique and the whole genome of Treponema pallidum, the causative agent of syphilis, has been sequenced, the diagnosis and treatment response of syphilis still rely on serologic tests. This review article will summarize most of the commonly used serologic tests for syphilis and briefly discuss the diagnostic dilemma in various clinical situations such as neurosyphilis, congenital syphilis and syphilis in HIV infected patients.

Keywords : Review, serologic diagnosis, syphilis

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