Hong Kong Dermatology & Venereology Bulletin

Volume 9 Number 4, December 2001

Evidence Based Medicine in Dermatology: Minocycline and Acne: from Clinical to Literature Review

Dr. C. W. Su
Social Hygiene Service (Dermatology), Department of Health, Hong Kong

Minocycline is one of the tetracyclines frequently used in the treatment of acne. There is a lack of consensus over the relative risk and benefits of minocycline in the treatment of acne. Starting from a clinical scenario, a literature search was initiated for the best available evidence on this subject. A Cochrane systemic review located 27 randomized controlled trials on the efficacy and risk of minocycline in treating mild to moderate acne. The trials were generally of insufficient size and quality to meet requirements of the systemic review. Although minocycline is an effective treatment for mild to moderate acne vulgaris, there was no reliable randomized controlled trial evidence to justify its continued first line use, given the price and concerns about safety that still remains.

Keywords : Acne, minocycline, randomized controlled trials

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