The Hong Kong Journal of Sports Medicine and Sports

Volume XIV, May 2002
Abstract

THE EFFECT OF AGING AND AEROBIC EXERCISE ON MITOCHONDRIAL DNA DELETIONS IN RAT LIVER

SHI QINGDE, YANG XIRANG
Department of Kinesiology
Beijing University of Physical Education, China

ZHANG YONG
Tianjin Research Institute of Sports Medicine, China

JIE JINLEI
Institute of Physical Education
Liaoning Normal University, China

LIU SHUSEN
State Key Laboratory of Biomembrane & Membrane Biotechnology
Institute of Zoology, Chinese Academy of Sciences, China

Aging is associated with alterations in mitochondrial functions. Mitochondrial DNA mutation probably plays an important role in the decrease of mitochondrial function and the increase of reactive oxygen species. In the present experiment, we detected deletions of mitochondrial DNA in the liver of 22 months old rats by using PCR technique. No deletion was detected in 3 months old rats. Three-month swim training reduced the frequency of mitochondrial DNA deletions in 22 months old rats. The activities of mitochondrial respiratory chain complexes I and IV in the liver of rats decreased significantly compared with young rats. Both complexes activities increased significantly in trained rats. The results indicate that aerobic exercise can reduce the frequency of mitochondrial DNA deletions and preserve mitochondrial functions in rats at old age.


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