The Hong Kong Journal of Sports Medicine and Sports

Volume XIV, May 2002
Abstract

THE EFFECT OF AEROBIC TRAINING ON THE GENE EXPRESSION OF NEUROPEPTIDE Y IN RAT HYPOTHALAMUS

YING ZHANG, FEIYUN FENG, HAO WU
Department of Human Sports Science
Beijing University of Physical Education, China

Neuropeptide Y (NPY) is a polypeptide which contains 36 amino acid. It was identified and separated from the brain of pig by Tatemoto in 1982. It is one of pancreatic polypeptide family members and is distributed widely in central nervous system and many organs (Dunont et al., 1992). It has close relationship with the important physiological regulation of dietetic action, breathing, smooth muscle contraction and neuroendocrine function in hypothalamus. NPY is one of the high content neuropeptides in central nervous tissue. People are now paying more and more attention to NPY's important biological functions and its research has recently become a hot topic (Kalra, 1996 & 1997 and Zarjevski et al., 1993). As we know, central nervous system is the important regulator of energy balance, but we know little about the effect of exercise on NPY in hypothalamus. The purpose of the present study is to investigate the effect of aerobic exercise on the gene expression of NPY in rat hypothalamus and to make primary study on the neuroendocrine mechanism of body fat loss by exercise.


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