| Abstract |
Sze-Kit Yuen
skit@alumni.cuhk.net
Sai-Ping Yong
Wilson Man-Shan Tsui, Department of Pathology, Caritas Medical Centre, Kowloon, Hong Kong SAR, China.
Fung-Yee Siu
Hing-Sum Tsui
King-On Cheung
Renal Unit, Department of Medicine and Geriatrics, Caritas Medical Centre, Kowloon, Hong Kong SAR, China.
Kimura’s disease is a rare condition of unknown etiology. It has been reported to be associated with nephrotic syndrome, but the causal relationship and etiological mechanism have not been confirmed. We report a case of steroid-responsive minimal-change nephrotic syndrome with immunoglobulin M deposits 2 years after the diagnosis of Kimura’s disease. A review of the English-language literature from 1998 to May 2004 revealed a total of eight cases of nephrotic syndrome in patients with Kimura’s disease. Six had nephrotic syndrome before the diagnosis of Kimura’s disease was made, four of whom needed dialysis. The relationship between Kimura’s disease and nephropathy is discussed.
Key words: Kimura's disease, eosinophilia, nephrotic syndrome, minimal-change nephrotic syndrome, immunoglobulin M
木村氏病是一種原因不明的罕見疾病，據報告指出可能與腎病症候群有關，但兩者間的確實關係仍然有待證實。以下為一例在木村氏病診斷後 2 年，出現類固醇反應性（steroid-responsive）微小變化性腎病症候群、兼具免疫球蛋白M沉積的個案。本文作者對 1998 年至 2004 年 5 月的英文醫學文獻作出回顧，共搜集了 8 例發生腎病症候群的木村氏病個案，其中 6 例於木村氏病診斷前已患有腎病症候群，4 例需接受透析治療。在本文中，作者亦對木村氏病與腎病症候群之間的可能關係作出討論。