Hong Kong Journal of Nephrology

Volume 6 Number 2, 2004

Update on the Biocompatibility of Hemodialysis Membranes

Nicholas A. Hoenich
School of Clinical Medical Sciences, University of Newcastle, Newcastle Upon Tyne, United Kingdom.

The blood of patients treated by dialysis is repeatedly exposed to foreign materials contained in the extracorporeal circuit, within which the membrane contained in the dialyzer is the largest element. Traditionally, the membrane was considered simply as a barrier between the blood and the dialysis fluid. However, the contact is also associated with the activation of coagulation, immune and cellular pathways, and the importance of repeated contact (often broadly referred to as “biocompatibility”) has become an important clinical issue. Links between renal failure, dialysis and inflammation, and the role played by dialysis fluid has further focused on the membrane. The purpose of this paper is to review the recent developments in hemodialysis membranes, and to discuss their biocompatibility and role played in morbidity and mortality associated with dialysis treatment.

Key words: hemodialysis, biocompatibility, membrane, endotoxin

對於長期接受血液透析的病人,其血液必需重複暴露於體外的環境中,其中透析裝置的人造半透膜元件為最主要的部分。半透膜不僅是血液與透析液間的一道屏障,更可能會激發一系列的生物效應,包括凝血與免疫系統的活化。事實上,半透膜與透析接受者的生物融和性( biocompatibility),是決定透析治療成功與否的主要因素之一,近年來亦已成為血液透析研究的重要課題。本文回顧了近年血液透析半透膜的發展狀況,並對其生物融和性與透析治療長期預後間的可能關係作出探討。

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