Hong Kong Journal of Nephrology

Volume 4 Number 1, 2002

Comparison of clinical course and outcome of hypophosphatemia with and without oral phosphate supplementation in the first year after renal transplantation: a single-center retrospective study

JGensy Mei-Wa TONG, Siu-Ka MAK, Kin-Yee LO, Ping-Nam WONG, Andrew Kui-Man WONG
Renal Unit, Department of Medicine, Kwong Wah Hospital, Hong Kong.

Introduction: Phosphate retention is a hallmark of chronic renal failure. The hypophosphatemia that occurs in the early post-renal transplantation period may represent the end result of the rapid transcellular shift of phosphate between body compartments rather than phosphate depletion. The common practice of phosphate replacement after renal transplantation should be re-evaluated.

Methods: The changes of serum phosphate over the first 12 months after renal transplantation were analyzed retrospectively in 30 new renal transplant recipients. Group A included nine normophosphatemic patients who did not require a phosphate supplement. Group B included 13 hypophosphatemic patients who were given a titrated dose of an oral phosphate mixture. Group C included eight hypophosphatemic patients who were not given phosphate supplementation.

Results: There was no difference in the duration of hypophosphatemia in Groups B and C. No complications of hypophosphatemia were found in patients in Groups B and C. A high serum phosphate level before transplantation was the single factor associated with post-transplantation hypophosphatemia. No predictors of serum phosphate level after renal transplantation were found.

Conclusion: Phosphate supplementation did not alter the clinical course and outcome of hypophosphatemia after kidney transplantation. (Hong Kong J Nephrol 2002;4(1):39-42)

Key words: Hypophosphatemia/metabolism, Osteopetrosis/therapy, Phosphates, Renal transplantation

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