Jian-Hong ZHANG, Xiao-Feng HE, Min HAN
Division of Nephrology, Department of Internal Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Objective: Blocking early C-reactive protein-mediated inflammatory reaction may have therapeutic implications in improving the prognosis of acute renal failure with severe ischemic-reperfusion injury. Therefore, the role of serum C-reactive protein in acute renal ischemic-reperfusion injury was investigated.
Methods: Fourteen New Zealand albino rabbits were selected and divided into
a treated and a control group at random. An acute renal ischemia-reperfusion
injury model was induced by clamping the right renal artery for 45 minutes with
simultaneous contralateral nephrectomy, followed by right renal reperfusion.
The treated group was injected with dexamethasone (1 mg/kg) 2 minutes before
renal reperfusion. Serum C-reactive protein, blood urea nitrogen, creatinine,
and urine volume were recorded at designed time phases in both groups. Data
were expressed as mean
Results: In the control group, there was a steady increase of serum C-reactive protein that reached its peak at 6-hour reperfusion, and a positive correlation between C-reactive protein and blood urea nitrogen and creatinine (r = 0.62 and 0.53, respectively); there was a negative correlation between C-reactive protein and urine volume (r = -0.52). Compared with the control group, C-reactive protein values in the treated group remained mainly in the baseline levels after reperfusion, with C-reactive protein peaking at 4-hour reperfusion (p<0.01), whereas urine volume increased significantly (p<0.01).
Conclusions: This study indicates that C-reactive protein is involved in the pathogenesis of acute renal ischemic-reperfusion injury; blocking early C-reactive protein-mediated inflammatory reaction may have therapeutic implications in improving the prognosis of acute renal failure with severe ischemic-reperfusion injury. (Hong Kong J Nephrol 2002;4(1):39-42)
Key words: C-reactive protein, Creatinine/urea, Dexamethasone, Kidney failure, Acute
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