Comparison of Magnetic Resonance Spectroscopic Imaging and Single Voxel Magnetic Resonance Spectroscopy for Suspected Recurrent Brain Tumour or Radiation Necrosis
YL Chan,1 H Schlemmer,2
DKW Yeung,3 T Wilhelm,4
1Department of Diagnostic Radiology and Organ Imaging,
3Department of Clinical Oncology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong,
2Department of Oncological Diagnosis and Therapy,
4Department of Biophysics and Medical Radiation Physics, German Cancer Research Centre, Heidelberg, Germany
Objective: To qualitatively and quantitatively compare spectra
obtained on single voxel spectroscopy and magnetic resonance spectroscopic imaging
in suspected recurrence of brain tumour or radiation necrosis.
Patients and Methods: Six patients with suspected recurrence of brain tumour or radiation necrosis were studied with single voxel spectroscopy and magnetic resonance spectroscopic imaging using the point-resolved spectroscopy technique, a repetition time of 1500 ms and an echo time of 135 ms.
Results: A high correlation in metabolite ratios obtained from single voxel spectroscopy and magnetic resonance spectroscopic imaging was seen. A tendency to obtain lower Choline/N-acetyl-aspartate ratios on magnetic resonance spectroscopic imaging compared with single voxel spectroscopy was noted.
Conclusion: The threshold established for the differentiation of recurrent tumour from necrosis using single voxel spectroscopy may need to be adjusted when magnetic resonance spectroscopic imaging is performed for the measurement of metabolite ratios. (J HK Coll Radiol 2001;4:259-263)
Key Words: Brain tumor, recurrent, Magnetic resonance spectroscopy,
Nuclear magnetic resonance, biomolecular, Radiation injuries
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