Airways Disease in AIDS: HRCT Features
RT Dwyer, A Taranto
Department of Radiology, Westmead Hospital, Westmead, Australia
Purpose: To assess clinicopathological and radiological findings in patients with airways disease in Acquired Immune Deficiency Syndrome (AIDS); describe imaging features and possible pathogenesis.
Materials and methods: High resolution thoracic computed tomography (HRCT) studies of eight patients presenting with respiratory pathology were retrospectively analysed. Results of imaging, spirometry, serology and microbiology were correlated.
Results: Mean interval between AIDS presenting illness and HRCT study was 49.2 months. On HRCT all patients demonstrated bibasal cylindrical bronchiectasis with bronchiolitis and six had concurrent paranasal sinus disease.
Conclusion: Bronchiectasis, bronchiolitis and paranasal sinusitis form part of the respiratory disease spectrum in AIDS. Recent description of these entities probably reflects chronic pathology in longer-term AIDS survivors. Pathogenesis is undetermined but may represent direct viral effect upon respiratory epithelium, aspiration of infected sinus secretions or immunological mechanisms. (J HK Coll Radiol 2001;1:74-79)
Key words : High resolution thoracic computed tomography (HRCT), Acquired Immune Deficiency syndrome (AIDS), Bronchiectasis, Bronchiolitis, Sinusitis
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