Journal of Hong Kong College of Radiologists

Volume 4 Number 1, 2001

T3-T4 Squamous Cell Carcinoma of the Larynx Treated with Radiation therapy

WM Mendenhall1, RJ Amdur1, AA Mancuso2, RW Hinerman1, DB Villaret3, RR Carroll4, SP Stringer3
1Department of Radiation Oncology, 2Department of Radiology, 3Department of Otolaryngology, 4Department of Medicine, Division of Hematology/Oncology, University of Florida College of Medicine, Gainesville, Florida,USA

The purpose of this article is to review the results of radiation therapy (RT) alone or combined with a planned neck dissection for T3-T4 squamous cell carcinoma of the larynx. The roles of altered fractionation and adjuvant chemotherapy will also be addressed. Local control after RT is approximately 65% for patients with T3 glottic and supraglottic carcinoma. The likelihood of local control is inversely related to tumor volume and, for those with glottic cancers, is adversely influenced by cartilage sclerosis on pretreatment CT of the larynx. Local control after radiotherapy is approximately 60% for T4 glottic cancers and 50% for T4 supraglottic carcinomas. The probability of severe complications is related to primary site and T stage. (J HK Coll Radiol 2001;1:27-36)

Key words : Laryngeal neoplasms, Radiotherapy, Squamous cell carcinoma, Treatment outcome

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