Shang Yukun, Kong Lingshan,
Pan Wenzhou, Cui Bin, Xie Mingxuan
Department of Nuclear Medicine, Changhai Hospital, Second Military Medicine University, Shanghai, 200433, China
A 56-year-old woman presented with 5-year history of pain and swelling of right hip. Four operations had been performed on the patient. The pathological diagnosis was low-grade malignant fibrous histiocytoma (MFH) of soft tissue. In fasting state, the patient received 155 MBq (4.2 mCi) of 18F-FDG intravenously. A whole-body PET study was performed with image acquisition starting at 50min after 18F-FDG injection. Emission and 137Cs-source transmission study were obtained. The attenuation corrected whole-body images were reconstructed by iteration. 18F-FDG PET images showed merging focuses of radiotracer accumulation in the right hip's soft tissue mass as well as the right iliac bone and the upper end of right femur. The maximal standard uptake value (SUVmax) was 7.3. Histological grading of soft tissue tumors is challenging because large heterogeneous tumor masses may cause sampling errors with underestimation of aggressiveness. The studies demonstrated increased uptakes of 18F-FDG in the patients with intermediate- and high-grade MFH. 18F-FDG PET imaging may be used to differentiate more aggressive MFHs from less aggressive ones and detect local recurrence and distant metastases.
Key Words: Malignant fibrous histiocytoma; 18F-FDG; PET
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