Asian Journal of Nuclear Medicine
亞洲核醫學雜志

Volume 2 Number 1, March 2002
Abstract

99mTc標記心肌灌注顯像劑用於腫瘤陽性顯像研究進展

邢詩安,張永學,安銳
華中科技大學同濟醫學院附屬協和醫院,核醫學科,武漢 430022,中國

腫瘤陽性顯像具有較高的靈敏度和特異性,易於對腫瘤的原發、復發以及轉移作出初步的定性、定位診斷。99mTc標記心肌灌注顯像劑用於腫瘤陽性顯像產品來源方便、穩定、操作簡便,圖像質量好,便於常規應用。本文綜述了99mTc-sestamibi,99mTc-tetrofosmin,99mTc-furifosmin,和99mTc-N-NOET四種用於腫瘤陽性顯像的99mTc標記心肌灌注顯像劑的制備及質量控制、濃集機制及臨床應用價值。

【關鍵詞】99mTc-sestamibi;99mTc-tetrofosmin;99mTc-furifosmin;99mTc-N-NOET;腫瘤顯像

A review of 99mTc labeled myocardial imaging agents for tumor-positive imaging

Xing Shian, Zhang Yongxue, An Rui
Huazhong University of Science and Technology, Union Hospital, Department of Nuclear Medicine, Wuhan 430022, China

The tumor-positive imaging with high sensitivity and specificity was useful in primary tumor and recurrences and metastases. The 99mTc labeled myocardial imaging agents are easily available and stable and the radiochemical purity is high. 99mTc is the preferred choice in routine works because its physical properties. The preparation, quality control, mechanism of accumulation and the clinical use of 99mTc-sestamibi, 99mTc-tetrofosmin, 99mTc-furifosmin, and 99mTc-N-NOET were reviewed.

Key Word: 99mTc-sestamibi; 99mTc-tetrofosmin; 99mTc-furifosmin; 99mTc-N-NOET; tumor imaging



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