Asian Journal of Nuclear Medicine
亞洲核醫學雜志

Volume 2 Number 1, March 2002
Abstract

糖尿病患者血清、尿液層粘蛋白水平與腎小球濾過率的相關性研究

李建林1,王林濤2,黃濤2
1青島大學附屬煙台毓璜頂醫院核醫學科,煙台 266100,中國
2山東省萊州市人民醫院平裡店、大原分院,萊州 261414,中國

目的 探討糖尿病患者血清、尿液層粘蛋白(Laminin,LN)水平與腎小球濾過率(GFR)之間的相關關係。方法 採用放射免疫法(RIA)測定75例糖尿病患者和42例正常人血清及尿液中LN的水平,99mTc-DTPA腎動態顯像方法進行腎小球濾過率的檢測。結果 (1)糖尿病腎病組血清、尿液LN水平明顯高於糖尿病無腎病組(P<0.05)及對照組(P<0.01),糖尿病組無腎病組血清、尿液LN水平高於對照組(P<0.05);糖尿病腎病組GFR明顯低於糖尿病無腎病組(P<0.05)及對照組(P<0.01);總糖尿病組血清、尿液LN水平均顯著高於對照組(P<0.05),而GFR低於對照組(P<0.05)。(2)病程<1年者其GFR高於對照組(P<0.05),病程>10年者低於對照組(P<0.05);(3)糖尿病患者血清、尿液LN水平與GFR均呈顯著負相關(r分別為-0.62、-0.52,P<0.01)。結論 LN可能促進GFR的改變,在糖尿病腎病微血管病變機制中起著重要的作用,可以作為早期診斷糖尿病腎病的一項重要指標。

【關鍵詞】糖尿病;層粘蛋白;腎小球濾過率

The relationship of serum and urinary laminin and glomerular filtration rate in diabetes mellitus

Li Jianlin1, Wang lintao2, Huang Tao2
1 Department of Nuclear Medicine, Yantai Yuhuangding Hospital of Qingdao College, Yantai, 264000,China
2 The People's Hospital of Laizhou, Laizhou 261414, China

Objective To observe the relationship of serum and urinary laminin and glomerular filtration rate(GFR) in diabetes mellitus. Methods The level of serum and urinary laminin was measured by radioimmunoassay, GFR acquired by 99mTc diethylenetriamine pentaacetic acid (99Tcm-DTPA), renal dynamic imaging in 75 diabetes mellitus and 42 normal subjects. Results (1) The level of serum LN (136.30±11.20 ng/ml) and urinary LN (31.76±5.77 ng/ml) in diabetic nephropathy was significantly higher than that in diabetes without nephrosis group(P<0.05)and control group(P<0.01),the level of serum LN(126.54±6.98 ng/ml) and urinary LN(26.27±3.81 ng/ml)in diabetes without nephrosis group was significantly higher than that in control group(P<0.05);the GFR of diabetic nephropathy(78.84±10.79 ng/ml) was significantly lower than that in diabetes without nephrosis group(P<0.05)and control group(P<0.01);the level of serum (131.49±10.74 ng/ml) and urinary LN (29.05±5.60 ng/ml) in diabetes mellitus was significantly higher than that in control group(P<0.05),but GFR was significantly lower than that in control group(P<0.05). (2)The value of GFR in diabetes mellitus lasted less than 1 year was higher than that of control group(P<0.05),but inverse in diabetes mellitus more than 10 years(P<0.05). (3)The level of serum and urinary LN had significantly negative correlation with GFR(P<0.01). Conclusion LN may accelerates the alteration of GFR and causes microangiopathy of diabetic nephropathy. It may be an important indicator in the diagnosis of the early diabetic nephropathy.

Key Words: Diabetes mellitus; Laminin; Glomerular filtration rate



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