Asian Journal of Nuclear Medicine
亞洲核醫學雜志

Volume 2 Number 1, March 2002
Abstract

膀胱腫瘤患者血清透明質酸與層粘蛋白的檢測與臨床意義

李令勳1,尤克強2,丁國富1
1新疆石河子大學醫學院第一附院泌尿外科,石河子832008,中國
2山東省煙台市海洋醫院外科,煙台 264000,中國

目的 探討膀胱腫瘤患者血清透明質酸(Hyaluronic Acid, HA) 與層粘蛋白(Laminin, LN) 的變化及其臨床意義。方法 採用放射免疫分析法分別測定34例膀胱腫瘤及30例對照組術前與術後血清HA、LN含量。結果 膀胱腫瘤組術前血清HA、LN含量均顯著高於對照組(P<0.01),術後明顯下降,手術前後血清HA、LN含量差異有顯著性意義(P<0.05);浸潤性膀胱腫瘤組(T2、T3、T4)與淋巴結轉移組血清HA、LN含量均明顯高於表淺性膀胱腫瘤組(Tis、Ta、T1)(P<0.05)與無淋巴結轉移組(P<0.01)。結論 HA與LN參與膀胱腫瘤的惡性生物學行為,可能成為重要的輔助診斷及病情監測指標。

【關鍵詞】 膀胱腫瘤;透明質酸;層粘蛋白;放射免疫分析法

Detection of hyaluronic acid and laminin in serum of patients with urinary bladder tumors

Li Lingxun1, You Keqiang2, Ding Guofu1
1 Department of Urology, The First Hospital, Medical College of Shihezi University, Shihezi 832008,China.
2 Department of Surgery, Haiyang Hospital of Yantai, Shandong Province, Yantai 264000, China.

Objective To investigate the serum Hyaluronic Acid (HA) and laminin (LN) level and its clinical significance in bladder tumors. Methods Serum samples from 34 patients with bladder tumor and 30 cases as control group were analyzed by radioimmunoassay. Results The results showed that the HA and LN levels of serum in patients with bladder tumors were significantly higher than that in control group(P<0.01)before operation, and decreased significantly after operation. The serum levels of HA and LN in infiltrated tumors were higher than that in superficial tumors(P<0.05). The markers in patients with lymph node metastasis were higher than that without lymph node metastasis(P<0.01). Conclusion HA and LN take part in the malignant biology behavior of bladder tumors. They may be the important markers in assisting diagnosis and disease monitoring.

Key words : Tumor of bladder; Hyaluronic Acid; Laminin; Radioimmunoassay



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