Asian Journal of Nuclear Medicine
亞洲核醫學雜志

Volume 2 Number 1, March 2002
Abstract

系統性紅斑狼瘡患者外周血淋巴細胞生長激素受體和泌乳素受體的研究

李鋒1,饒俊昌1,陸雲2,馮樹芳1,鄧守真2
復旦大學附屬華山醫院1皮膚科,2核醫學科,上海200040,中國

目的 探討生長激素受體和泌乳素受體在系統性紅斑狼瘡(SLE)中的意義。方法 用放射受體分析(RLBA)測定25例SLE活動期患者、20例靜止期患者和20例年齡、性別匹配正常對照組外周血單個核細胞(PBMC)的生長激素受體(GHR)和泌乳素受體(PRLR)的容量;用放射免疫分析(RIA)測定血清生長激素(GH)和泌乳素(PRL)。結果 SLE活動期患者PRLR容量(SB 6.7±2.3%,TB 10.5±4.6%)顯著高於SLE靜止期患者(SB 2.5±0.8%,TB8.5±4.3%)及正常對照組(SB1.9±1.2%,TB9.3±6.4%)(P﹤0.05);SLE活動期患者GHR容量(SB 4.5±2.8%,TB7.5±4.6%)顯著高於SLE靜止期患者(SB 1.8±1.2%, TB5.5±5.3%)及正常對照組(2.7±2.3%,TB6.4±5.0%)(P﹤0.01);PRLR和GHR特異結合率與SLE疾病活動性指標(SLEDAI)呈正相關。SLE患者外周血單個核細胞的GHR容量和PRLR容量與血清生長激素和泌乳素水平一致。SLE活動期血清生長激素和泌乳素升高,外周血單個核細胞的GHR容量和PRLR的容量也升高。結論 SLE患者PBMC高GHR容量和PRLR容量與SLE的發生有一定關係。

【關鍵詞】系統性紅斑狼瘡;生長激素;泌乳素;受體

Study on GH receptors and PRL receptors on peripheral blood lymphocytes in patients of systemic lupus erythematosus

Li Feng1, Rao Junchang1, Lu Yun2, Feng Shufang1, Deng Shouzhen2.
1Department of Dermatology, 2Department of Nuclear Medicine, Affiliated Huashan Hospital, Fudan University, Shanghai 200040, China

Objective To study the association of growth hormone (GH) and prolactin (PRL) and their receptors in patients with systemic lupus erythematosus. Methods We measured serum PRL and GH level with radioimmunoassay (RIA) in 25 untreated patients of active SLE, 20 patients of inactive SLE and in 20 gender-age-paired control subjects. We also measured peripheral blood lymphocytes (PBMC) GH receptors (GHR) and PRL receptors (PRLR) with radioactive binding ligand assay (RLBA). Results The specific binding (SB) ratio of PRLR was 6.7±2.3%(x±s), the total binding ratio was 10.5±4.6% (x±s) in active patients of SLE. The SB of PRLR in active patients was higher than that of inactive patients(SB 2.5±0.8%, TB 8.5±4.3%) and that of 20 control subjects(SB 1.9±1.2%, TB,9.3±6.4%) ( P<0.05). The SB of GHR in active patients of SLE (SB 4.5±2.8%,TB7.5±4.6%) was significantly different from that of inactive patients (SB 1.8±1.2%,TB5.5±5.3%) and that of normal groups(SB 2.7±2.3%,TB6.4±5.0%)( P<0.01).The TB of GHR was not significantly different among them (P>0.05). The serum GH and PRL level was also significantly increased in active patients of SLE (P<0.05). Conclusion The increase of GHR and PRLR in the PBMCs of SLE was certainly associated with pathogenesis of SLE.

Key Words : Systemic lupus erythematosus; Growth hormone; Prolactin; Receptor



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