Asian Journal of Nuclear Medicine

Volume 1 Number 1, April 2001



An analysis on the level changing of UET and SET in blood and urine in early stage of kidney disease caused by diabetes

LIU Juzhen, YANG Wenying, CAI Tietie. Nuclear Department Inner Mongolia Hospital, Huhehot 010017, China.

Objective To study the relationship between UET and SET variation and early changes of diabetic nephropathy. Methods UET and SET were measured in 24 patients with diabetes, 19 with early stage diabetic nephropathy, 21 with advanced diabetic nephropathy and 30 normal as contrast. Results Apparent uprise of UET and SET was observed in all patients when compared to normal contrasts (P<0.01). The levels of UET and SET uprose as early as urinary albumin excretion rate was less than 20ug/min in diabetics. A notably positive correlation between UET and urinary β2-macroglobulin was revealed (P<0.05). Conclusion UET and SET levels uprose as long as diabetic nephropathy deteriorated. As a result, UET and SET may act as sensitive indices in diagnosing early stage diabetic nephropathy. (Asian J Nucl Med 2001;1:60-61)

Key Words : Endothelin; diabetes nephropathy; radioimmunoassay.

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