目的：探討 153Sm-EDTMP治療肺癌多發性骨轉移患者的療效。方法：根據病人的病情及體重，一般按18.5~25.9 MBq/Kg計算，靜脈一次性給藥，每月一次，三次為一療程。結果：治療後疼痛反應療效Ⅰ級19例（24.3%），Ⅱ級46例（59%），Ⅲ級13例（16.7%），總有效率為83.3%。骨轉移灶療效Ⅰ級3例，Ⅱ級6例，好轉率達11.5%。腺癌、鱗癌效果優於小細胞癌。結論：153Sm-EDTMP治療肺癌多發性骨轉移是一種安全可靠、有效的方法。
Clinical applications of 153Sm-EDTMP in treatment of multiple bone metastases in 78 patients with lung cancer
XIAO Guoyou; LI Dangsheng; LIANG Yihua; YAO Xinjuan. Department of nuclear medicine, Hospital of oncology, Guangxi Medical University. Nannin 530021,China.
Objective To evaluate the effect of 153Sm-EDTMP in treating patients with lung cancer and multiple bone metastases. Methods A dose of 18.5~25.9MBq/Kg 153Sm-EDTMP was administered once a month to each patient through vein injection according to disease severity and body weight. 3 injections made up one therapy cycle. Results Pain relieves were obtained in 65 patients, with an effective rate of 83.3%. Pain relief of gradeⅠ was observed in 19 patients(24.3%), grade Ⅱ in 46 patients(59%) and gradeⅢ in 13 patients(16.7%), respectively. Lesions of bone metastases disappeared or shrunk in 9 patients, with a positive rate of 11.5%, which included 3 cases of gradeⅠ and 6 cases of gradeⅡ, respectively. Better effects were obtained in adenocarcinoma and squamous carcinoma than in small cell lung cancer. Conclusion 153Sm-EDTMP is safe and effective in treating patients with lung cancer and multiple bone metastases. (Asian J Nucl Med 2001;1:51-52)
Key Words : 153Sm-EDTMP; Therapy; Bone; Metastatic
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