Asian Journal of Nuclear Medicine
亞洲核醫學雜志

Volume 1 Number 1, April 2001
Abstract

風濕性心臟病二尖瓣狹窄患者血漿降鈣素基因相關銴峇漸眽懂定的臨床意義

劉春雨1 劉占鋒2 唐元升2
山東省立醫院1核醫學科,2心內科,濟南 250021,中國

目的 探討風濕性二尖瓣狹窄(MS)患者經皮二尖瓣球囊括張術(PBMV)前後血漿降鈣素基因相關(CGRP)及內皮素(ET)水平變化的臨床價值。方法 用放射免疫法(RIA)測定了30例MS患者PBMV前後血漿CGRP和ET水平,並與對照組相比較。結果 術前血漿CGRP水平顯著低於對照組(分別為 5.63±1.01pg/ml,P<0.001),術後第一天明顯升高(12.15±3.32pg/ml, P<0.001),以後繼續升高,而血漿ET水平則呈相反變化(P<0.001);CGRP與ET水平呈顯著負相關(r=-0.427, P<0.01)。結論 提示CGRP及ET水平變化在MS的病理生理改變中起著重要作用,其血漿水平可作為判斷MS病情及PBMV療效的一個指標。

【關鍵字】 二尖瓣狹窄;氣囊擴張術;降鈣素;基因;內皮素

The clinical significance of the levels of plasma calcitonin gene-related peptide and endothelin in patients with mitral stenosis

LIU ChunYu, LIU ZhanFeng, TANG YuanSheng. Shandong Provincial Hospital, Jinan 250021, China

Objective To evaluate the value of the levels of plasma calcitonin gene-related peptide (CGRP) and endothelin (ET) before and after percutaneous balloon mitral valvuloplasty (PBMV) in patients with mitral stenosis (MS). Methods The levels of plasma CGRP and ET before and after PBMV in 30 patients with MS were measured by radioimmunoassay, and were compared with the controls. Results The results showed that the level of CGRP before PBMV in MS patients was significantly lower than that of the controls (P<0.001), and increased after PBMV (P<0.001). The variability of the level of ET before and after PBMV in MS patients was reverse to CGRP (P<0.001). There was significant negative correlation between the level of CGRP and the level of ET (r=-0.427, P<0.01). Conclusions It is suggested that the level of CGRP and the level of ET may play a role in the pathophysiological process of MS, and the level of CGRP and the level of ET before and after PBMV may be a good parameter for evaluating the severity of MS and effect of PBMV. (Asian J Nucl Med 2001;1:45-46)

Key Words : Mitral valve stenosis; Transluminal coronary balloon dilalation; Calcitonin; Endothelin

 



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