Asian Journal of Nuclear Medicine
亞洲核醫學雜志

Volume 1 Number 1, April 2001
Abstract

兩種透析膜對腎功衰患者血清β2-MG透析效果的比較

陸雲、薛駿、林祥通、鄧守真、李鼎
上海復旦大學醫學院華山醫院,上海 200040,中國

目的 比較聚狠予M三醋酸膜透析器對維持性血透病人血清β2-微球蛋白(β2-MG)清除效果的影響。方法 維持性血透病人106名,隨機分成A、B二組。A組42人,採用三醋酸膜透析器(N-130E);B組64人,採用聚狠仇z析器(F6)。比較A、B二組透析前後血清β2-MG濃度清除效果。結果 A、B二組透析前血清β2-MG水平無明顯差異(46.74±19.46hg/L vs 47.49±16.71mg/L,P>0.05)。A組透前透後血清β2-MG濃度有顯著差異(46.74±19.46mg/L vs 39.76±17.66mg/L,P<0.05 =,透析後β2-MG顯著下降。B組透前、透後血清β2-MG濃度無顯著差異(47.49±16.7lmg vs 50.19±22.76mg/L,P>0.05)。結論 N-130E透析器在清除β2-MG效果方面優於F6透析器。

【關鍵字】 透析膜;β2微球蛋白

The effect of different dialyzer membrane on the clearance of serum β2-MG in maintenance hemodialysis patients

LU Yun, XUE Jun, LIN Xiangtong, DENG Shouzhen, LI Ding. Department of nuciear medician, Huashan Hospital, Fudan Medical Unlversity, Shanghai 200040,China.

Objective To investigate the effect of different membrane on the clearance of serum β2-MG in maintenance hemodialysis patients. Method 106 maintenance hemodialysis patients randomized divided into group A and group B. Group A used cellulose tiacetate membrane (N-130E), Group B used polysulfone membrane (F6). The levels of serum β2-MG before and after hemodialysis were compared in Group A and B, respectively. Results Before hemodialysis, the level of serum β2-MG was not significant different between Group A and B (46.74±19.46mg/L vs 47.49±16.71 mg/L, P>0.05). In Group A, compared with that before hemodialysis, the level of serum β2-MG after hemodialysis decreased significantly. (46.74±19.46mg/L vs 39.76±17.66 mg/L, before HD vs after HD, P<O.05). In Group B, thlere was no difference in the levels of serum β2-MG between before and after hemodialysis (47.49±16.71 mg/L vs 50.19±22.76 mg/L, P>0.05). Conclusion N-130E dialyzer is better than F6 dialyzer as the effect of clearance serum β2-MG is concerned. (Asian J Nucl Med 2001;1:43-44)

Key words : Dialyzer membrane; β2-microglobin



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