目的 評價 18F-FDG PET顯像對結直腸癌術後局部復發及遠處轉移的診斷價值。方法 對31例結直腸癌術後患者進行 18F-FDG PET顯像，結果評價應用目測法及半定量分析，計算腫瘤/正常攝取比值(T/N)及標準攝取值(SUV)，並與血清CEA水平、局部CT、核素骨顯像等常規檢查比較。結果 31例患者中，22例局部復發，9例為瘢痕，21例有遠處轉移。復發腫瘤SUV 5.37±1.92，瘢痕SUV 1.38±0.51，兩者具有極顯著性差異(P<0.001)，復發腫瘤T/N 5.20±2.62，瘢痕T/N 1.69±0.71，兩者具有極顯著性差異(P<0.001)。SUV與T/N具有正相關性(r=0.7759)。PET檢出了常規檢查陰性的19個轉移灶。結論 FDG PET顯像對CEA陰性復發、隱匿性復發和遠處轉移灶的診斷，特別是肝、肺轉移灶的診斷具有重要價值。
Evaluation of 18F-FDG PET imaging in the diagnosis of recurrence and distant metastases of colorectal cancer
ZHAO Jun, LIN Xiangtong,
GUAN Yihui, et al.
Department of Nuclear Medicine & PET Center, Huashan Hospital, Medical center of Fudan University. Shanghai 200040, China.
Objective: To assess the value of whole body positron emission tomography (PET) imaging with [18F] fluorodeoxyglucose (FDG) in the diagnosis of local recurrence and distant metastases postoperation of colorectal cancer. Methods: Whole body attenuation-corrected 18F-FDG PET imaging was performed in 31 patients previously surgery treated for colorectal cancer. The PET images were analyzed by visual and semi quantitative assessments with the target-to-normal ratio (T/N) and standardized uptake value (SUV) for local lesions. The PET results were compared to those of conventional examinations, which included serum CEA measurement, local CT scan, radionuclide bone scintigraphy. Results: Of 31 patients, local recurrence was revealed in 22, tissue scar in 9 and distant metastases in 21, respectively. The SUV of recurrence lesion was 5.37±1.92, significantly higher than that of scar tissues (1.38±0.51 P<0.001).The T/N ratio of malignant lesions was also significantly higher (5.20±2.62)than that of scar tissue(1.69±0.71,P<0.001). There was a positive correlation between SUV and T/N ratio(r=0.7759). PET detected 19 unsuspected metastases in conventional examinations. Conclusion: 18 F-FDG PET is highly valuable in the diagnosis of CEA negative occult recurrence and distant metastases, especially for the diagnosis of liver and lung metastases. (Asian J Nucl Med 2001;1:9-12)
Key Words : Colorectal neoplasm; Recurrence; Positron Emission Tomography; Fluorine-18-fluorodeoxyglucose
Back to Previous Page